Documentation
System requirements
OpenDDE runs entirely in Docker containers on your local machine. Here’s what you need.
Minimum requirements
| Component | Minimum | Recommended |
|---|---|---|
| RAM | 8 GB | 16 GB |
| CPU | 4 cores | 8+ cores |
| Disk | 10 GB free | 20 GB free |
| Docker | Docker Desktop 4.0+ | Latest version |
Supported operating systems
- macOS 12+ (Intel & Apple Silicon)
- Linux (Ubuntu 20.04+, Debian 11+, Fedora 36+)
- Windows 10/11 with WSL2 + Docker Desktop
Network requirements
The first run downloads Docker images and data (~5 GB). After that, OpenDDE needs internet access for:
- UniProt API (fetching protein data)
- ChEMBL API (fetching ligand data)
- AlphaFold Database (downloading structures)
- Anthropic API (AI assistant, optional)
All computational engines (P2Rank, RDKit, ImmuneBuilder) run locally — no cloud GPU required.